Method of treating an immune-related disorder or disease associated with an organ or tissue transplant with a combination of an anti-CD2 antibody and a CTLA-4 co-stimulation blockade

A method of treating or preventing an immune-related disorder or disease associated with a kidney transplant or a transplant of kidney tissue in a subject in need thereof, the method comprising:

• a) administering more than one dose of an anti-CD2 antibody or an antigen-binding fragment thereof to the subject;
• and
• b) administering a CTLA-4 co-stimulation blockade to the subject, wherein the CTLA-4 co-stimulation blockade comprises the amino acid sequence of SEQ ID NO:
• 22:
• wherein a dose of about or at least about 0.6 mg/kg of the anti-CD2 antibody or antigen-binding fragment thereof is administered to the subject on the same day that the kidney or tissue thereof is transplanted into the subject, and wherein another dose of the anti-CD2 antibody or antigen-binding fragment thereof is administered to the subject once within two weeks after the kidney or tissue thereof is transplanted into the subject;
• and wherein the anti-CD2 antibody or antigen-binding fragment thereof comprises:
• i) a heavy chain variable region CDR1 comprising the amino acid sequence of SEQ ID NO:
• 3;
• ii) a heavy chain variable region CDR2 comprising the amino acid sequence of SEQ ID NO:
• 4;
• iii) a heavy chain variable region CDR3 comprising the amino acid sequence of SEQ ID NO:
• 5;
• iv) a light chain variable region CDR1 comprising the amino acid sequence of SEQ ID NO:
• 6;
• v) a light chain variable region CDR2 comprising the amino acid sequence of SEQ ID NO:
• 7;
• and
• vi) a light chain variable region CDR3 comprising the amino acid sequence of SEQ ID NO:
• 8.