Coronavirus vaccine
AssigneeImperial College Innovations Limited
InventorsRobin Shattock, Paul McKay, Anna Blakney
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Abstract
The invention relates to vaccines, and in particular, to vaccines for preventing, treating or ameliorating coronavirus infections, such as severe acute respiratory syndrome coronavirus (SARS), SARS-CoV-2 and Middle East respiratory syndrome-related coronavirus (MERS). The invention is especially concerned with self-amplifying RNA replicons and genetic constructs or vectors encoding such RNA replicons, and their use in vaccine delivery for preventing infections of coronavirus. The invention extends to pharmaceutical compositions comprising such RNA constructs, and methods and uses thereof.
Claims32
A self-amplifying RNA (saRNA) construct comprising a nucleic acid sequence encoding a coronavirus surface glycoprotein, or a fragment or variant thereof, wherein the RNA construct comprises a sequence, which encodes an innate inhibitor protein (IIP), which is capable of reducing or blocking the innate immune response to the saRNA.
Dependencies are inferred from the claim text.