Modulation of mTORCI activity and autophagy via CIB2-RHEB interaction
AssigneeUniversity of Maryland, Baltimore
InventorsZubair M. Ahmed, Saumil Sethna, Saima Riazuddin
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Abstract
Provided herein are compositions and methods for down-regulating mTORC1 signaling in a subject, comprising administering to the subject an effective amount of one or more compositions that promote increased levels or activity of CIB2 or a biologically active fragment or variant thereof in the subject.
Claims20
A method for treating a disease, condition or disorder by down-regulating mTORC1 signaling in a subject, comprising administering to the subject an effective amount of one or more compositions that increase activity of CIB2 or a biologically active fragment or variant thereof in the subject, wherein the subject is in need of treatment for the disease, condition, or disorder selected from the group consisting of macular degeneration and age-related macular degeneration, thereby downregulating mTORC1 signaling in the subject.
Dependencies are inferred from the claim text.