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US 12,661,384 B2Granted
Methods for inducing cell division of postmitotic cells
AssigneeThe J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Gladstone
InventorsTamer M. A. Mohamed, Deepak Srivastava
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Abstract
The present disclosure provides methods for inducing cell cycle reentry of postmitotic cell. The present disclosure further provides cells and compositions for treating diseases, such as cardiovascular diseases, neural disorders, hearing loss, and diabetes.
Claims13
A method of treating myocardial infarction (MI) in a subject in need thereof, comprising administering to the subject effective amounts of:
- a) a cyclin-dependent kinase-4 (CDK4);
- b) a cyclin D1 (CCND1);
- and
- c) a TGF-β inhibitor, a Wee1 inhibitor, or both.
1 more element
Dependencies are inferred from the claim text.