Compositions and methods of treating dry eye syndrome and other traumatized non-keratinized epithelial surfaces
AssigneeEye Care International, LLC
InventorsMatthew B. Dowling, Steven E. Lazar, Helga M. Gentile
Life of this patent
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Abstract
The present disclosure relates to a composition including non-autologous plasma or serum and a polymer; method of treating ophthalmic diseases (e.g., dry eye syndrome) or moisturizing and/or repairing non-keratinized surfaces including non-healing wounds with a composition including non-autologous plasma or serum and a polymer; and a therapeutic agent delivery device for delivery of the composition to the eye or a non-keratinized surface of a subject.
Claims20
An ophthalmic pharmaceutical composition formulated for topical administration and comprising plasma, a polysaccharide or derivative thereof, and an aqueous carrier,
- wherein the composition is 0.25% to 2.0% (w/w) polysaccharide, wherein the polysaccharide comprises chitosan, cellulose, carboxymethylcellulose, dextrin, dextran, pectin, alginic acid, agar, agarose, carrageenan, or hyaluronic acid, or a salt or derivative thereof,
- wherein the plasma is pooled from non-neonatal, allogenic plasma, and
- wherein (a) or (b) is true:
- (a) the polysaccharide or derivative thereof comprises a salt dissolved as an ion and counterion in the aqueous carrier, the counterion comprising a glutamate, lactate, citrate, hydrochloride, succinate, maleate, ascorbate, propionate, formate, carbonate or acetate counterion, or
- (b) the polysaccharide comprises chitosan.
Dependencies are inferred from the claim text.