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US 12,661,370 B2Granted
Amino acid salts of nicotinic acid ribosides as anti-aging agents
AssigneesJumpstart Fertility Pty Ltd, Life Biosciences, Inc.
InventorsSebastian Mario Marcuccio, Rohan David Joyce, Michel Wathier, Roland Dolle, Simon Tucker
Life of this patent
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Abstract
The present invention relates to amino acid salts of nicotinic acid ribosides and compositions thereof of Formula I, useful in the treatment of disorders and diseases associated with deficiencies in NAD+: wherein M1, R1, R2, and R3 are as described herein.
Claims18
A salt selected from the group consisting of:
- (S)-2-Ammonio-3-phenylpropanoate compound with 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridine-1-ium-3-carboxylate (1:1) (I-001);
- (2S,3S)-2-Ammonio-3-methylpentanoate compound with 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridine-1-ium-3-carboxylate (1:1) (I-002);
- (S)-2-Ammonio-3-(1H-indol-3-yl)propanoate compound with 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridine-1-ium-3-carboxylate (1:1) (I-003);
- 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium-3-carboxylate-(S)-6-amino-2-ammoniohexanoate (1:1) (I-004);
- 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium-3-carboxylate (S)-5-amino-2-ammonio-5-oxopentanoate (1:1) (I-005);
- 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium-3-carboxylate-(S)-2-ammonio-4-methylpentanoate (1:1) (I-006);
- 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium-3-carboxylate-(S)-2-ammonio-4-carboxybutanoate (1:1) (I-007);
- (S)-2-ammonio-3-methylbutanoate-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium-3-carboxylate (1:1) (I-008);
- (S)-2-ammonio-5-guanidinopentanoate-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium-3-carboxylate (1:1) (I-009);
- and
- 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium-3-carboxylate-(S)-2-ammonio-3-(1H-imidazol-4-yl)propanoate (1:1) (I-010).
8 more elements
Dependencies are inferred from the claim text.