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US 12,661,329 B2Granted
Methods of generating oligodendrocytes
AssigneeHadasit Medical Research Services and Development Ltd.
InventorsBenjamin Eithan Reubinoff, Etti Ben-Shushan
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Abstract
A method of generating human mature oligodendrocytes is disclosed. The method comprises contacting a cell population which comprises human pre-oligodendrocytes with an inhibitor of the MAPK/ERK pathway under conditions that allow the pre-oligodendrocytes to differentiate into mature oligodendrocytes. Use of the MAPK/ERK pathway inhibitor for treating diseases is also disclosed.
Claims13
A method of generating human mature oligodendrocytes comprising:
- (a) culturing human pluripotent stem cells under conditions that produce a cell population comprising pre-oligodendrocytes which express O4, wherein no more than 70% of the cells of said cell population are oligodendrocyte progenitor cells (OPCs);
- and
- (b) contacting said cell population which comprises said pre-oligodendrocytes with an inhibitor of the MAPK/ERK pathway under conditions that allow the pre-oligodendrocytes to differentiate into mature oligodendrocytes.
Dependencies are inferred from the claim text.