Hybrid polymer-ceramic particles, methods for preparing the same and uses thereof

A composition comprising a plurality of particles characterized by an average particle size in a range from 10 to 500 nm as determined by DLS, wherein each of the plurality of particles is a hybrid nanoparticle comprising:

• (i) an amphiphilic block-copolymer comprising at least one first block forming a hydrophobic core, and at least one second block having a water solubility greater than said first block;
• and
• (ii) a transition metal oxide consisting of titanium oxide in an amorphous state;
• wherein said transition metal oxide is bound to said amphiphilic block-copolymer;
• wherein the amphiphilic block-copolymer is a sole polymer in the composition;
• wherein the amphiphilic block-copolymer and the transition metal oxide are homogeneously distributed within the hybrid nanoparticle;
• wherein said at least one first block is PPG and wherein said at least one second block is PEG;
• and wherein said amphiphilic block-copolymer is a PEG-PPG block copolymer characterized by an average molecular weight (Mw) of between 500 and 20000 Da.