Antimicrobial AZO compounds and uses thereof
AssigneeThe Regents of the University of Colorado, a body corporate
InventorsDevatha P. Nair, Dylan Mori, Michael J. Schurr
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Abstract
Antimicrobial azo compounds include azobenzene monomers having a phenyl ring comprising a hydroxyl substituent group. The azobenzene monomers can be reacted with a polymeric material to form an antimicrobial coating that prevents growth of persistent biofilms. In some implementations, the azobenzene monomers can be used to coat the surface of a dental resin-based composite to prevent the formation secondary caries. In some implementations, the azobenzene coating can be used to disperse microbial biofilms through a photofluidization process (rapid photoisomerization) in addition to biochemically preventing formation of the microbial biofilm.
Claims16
A polymeric composition comprising:
- a polymer chain in a dental resin-based composite;
- and
- an azobenzene pendant group attached to the polymer chain, wherein the azobenzene pendant group includes a N═N double bond group and a phenyl ring having a hydroxyl substituent group, and wherein the azobenzene pendent group is attached via a linking group to the polymer chain at a ring carbon atom ortho to the N═N double bond group.
Dependencies are inferred from the claim text.