Systems for radioisotope generation and methods of preparation and administration

A radioisotope generator system comprising:

• a) a shielded reactor housing having a surface comprising an evacuation port, a loading port, and a saline flush port;
• b) a radioisotope generator column located within the shielded reactor housing and comprising an inlet and outlet port;
• and
• c) an adapter disk disposed on said shielded reactor housing comprises a ridge of material that extends around the said evacuation port, a ridge of material that extends around said loading port, and a ridge of material that extends around said saline flush port;
• wherein the inlet port is connected with the evacuation port, the outlet port is connected with the loading port, the evacuation port is used to evacuate the daughter radioisotope, the saline flush port is used to provide the eluent, the loading port is used to re-load the parent radioisotope into the generator column and the saline flush port is permanently connected with the loading port.