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US 12,656,592 B2Granted
Imaging systems with periscope well plates
OwnerGregor Horstmeyer, Robert Horstmeyer +1inventors
InventorsGregor Horstmeyer, Robert Horstmeyer, Paul Reamey
Life of this patent
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Abstract
An imaging system having multiple cameras can be used for simultaneously imaging the top and side of samples in wells of a wellplate under multiple illumination sources, with each well in the wellplate adjacent to a set of two angled optical elements configured for viewing the two opposite side of the well. The cameras, the wells, and the illumination sources are configured to match each other to provide a high throughput imaging system, which can be used for a wide range of applications including pharmaceutical drug discovery, toxicology and a patient specific oncology.
Claims18
An imaging system comprising
- multiple cameras;
- multiple illumination sources;
- a controller,
- wherein the controller is configured to control the multiple illumination sources to generate one or more illumination patterns to a well plate,
- wherein the controller is configured to control the multiple cameras to capture images of samples in wells of the well plate under an illumination pattern of the one or more illumination patterns,
- wherein the controller is configured to stop data collection from a third camera when an image captured by the third camera is in focus and shows a fully side view of a sample,
- wherein the well plate comprises multiple wells, wherein at least one well of the multiple wells is disposed between two adjacent optical elements, wherein a first optical element of the two adjacent optical elements is configured to reflect light from a first side of the well plate to a first side of the at least one well, with the multiple cameras disposed at the first side of the at least one well, wherein a second optical element of the two adjacent optical elements is configured to reflect light from second side opposite the first side of the well plate to a second side of the at least one well,
- wherein the multiple cameras and the well plate are configured so that the at least one well is positioned in a field of view of a first camera of the camera array,
- wherein the multiple cameras and the well plate are also configured so that the first optical element is positioned in the field of view of the first camera or in a field of view of a second camera of the multiple cameras,
- wherein the multiple cameras and the multiple wells are configured so that one of
- each well and an optical element adjacent to the each well are in a field of view of one or more cameras of the multiple cameras, or
- each camera of the multiple cameras is configured to capture images from at least one well or from an optical element adjacent to the at least one well.
9 more elements
An imaging system comprising
- multiple cameras;
- multiple illumination sources;
- a controller,
- wherein the controller is configured to control the multiple illumination sources to generate one or more illumination patterns to a well plate,
- wherein the controller is configured to control the multiple cameras to capture images of samples in wells of the well plate under an illumination pattern of the one or more illumination patterns,
- wherein the well plate comprises multiple wells, wherein at least one well of the multiple wells is disposed between two adjacent optical elements, wherein a first optical element of the two adjacent optical elements is configured to reflect light from a first side of the well plate to a first side of the at least one well, with the multiple cameras disposed at the first side, wherein a second optical element of the two adjacent optical elements is configured to reflect light from second side opposite the first side of the well plate to a second side of the at least one well,
- wherein the multiple cameras and the well plate are configured so that the at least one well is positioned in a field of view of a first camera of the camera array,
- wherein the multiple cameras and the well plate are also configured so that the first optical element is positioned in the field of view of the first camera or in a field of view of a second camera of the multiple cameras,
- wherein the controller is configured to stop data collection from a third camera when an image captured by the third camera is in focus and shows a fully side view of a sample.
6 more elements
Dependencies are inferred from the claim text.