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US 12,656,423 B2Granted
Fluorescence detection device and fluorescence detection method
AssigneeNational Institutes for Quantum Science and Technology
InventorsRyuji Igarashi, Tamami Yanagi, Kiichi Kaminaga
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Abstract
Provided is a technique of identifying fluorescence emitted from a measurement target, the measurement accuracy of the technique being improved by processing data also including background light. A fluorescence detection device includes: a first generating section that generates excitation light whose intensity is modulated and which excites a phosphor that emits fluorescence whose intensity varies according to magnetic resonance; and a second generating section that generates a magnetic field or an electromagnetic wave each of which causes the magnetic resonance so that the intensity of the fluorescence emitted from the phosphor is changed.
Claims9
A fluorescence detection device comprising:
- a first generating section that generates excitation light whose intensity is modulated and which excites a phosphor, wherein the phosphor contains at least one selected from the group consisting of:
- an NV center of a diamond which NV center contains a nitrogen atom that substitutes for a carbon atom and a vacancy defect that is adjacent to the nitrogen atom;
- an SiV center of a diamond which SiV center contains a silicon atom that substitutes for a carbon atom and a vacancy defect that is adjacent to the silicon atom;
- a VSiVC center of a silicon carbide crystal which VSiVC center contains a vacancy defect that substitutes for a silicon atom and a vacancy defect that is adjacent to the vacancy defect;
- and a VSi center of a silicon carbide crystal which VSi center contains a vacancy defect that substitutes for a silicon atom;
- a second generating section that generates a magnetic field which causes magnetic resonance so that intensity of fluorescence emitted from the phosphor is changed;
- the first generating section includes an excitation light generating part that generates the excitation light and a first modulating part that modulates the intensity of the excitation light with use of a carrier wave having at least one of a first frequency and a first phase;
- and
- the second generating section includes a magnetic field generating part that generates the magnetic field and a second modulating part that modulates intensity of the magnetic field with use of a carrier wave having at least one of a second frequency differing from the first frequency and a second phase differing from the first phase.
6 more elements
A fluorescence detection device comprising:
- a first generating section that generates excitation light whose intensity is modulated and which excites a phosphor, wherein the phosphor contains at least one selected from the group consisting of:
- an NV center of a diamond which NV center contains a nitrogen atom that substitutes for a carbon atom and a vacancy defect that is adjacent to the nitrogen atom;
- an SiV center of a diamond which SiV center contains a silicon atom that substitutes for a carbon atom and a vacancy defect that is adjacent to the silicon atom;
- a VSiVC center of a silicon carbide crystal which VSiVC center contains a vacancy defect that substitutes for a silicon atom and a vacancy defect that is adjacent to the vacancy defect;
- and a VSi center of a silicon carbide crystal which VSi center contains a vacancy defect that substitutes for a silicon atom;
- a second generating section that generates an electromagnetic wave, which causes magnetic resonance so that intensity of fluorescence emitted from the phosphor is changed;
- the first generating section includes an excitation light generating part that generates the excitation light and a first modulating part that modulates the intensity of the excitation light with use of a carrier wave having at least one of a first frequency and a first phase;
- and
- the second generating section includes an electromagnetic wave generating part that generates the electromagnetic wave and a third modulating part that modulates intensity or a frequency of the electromagnetic wave with use of a carrier wave having at least one of a second frequency differing from the first frequency and a second phase differing from the first phase.
6 more elements
A fluorescence detection method comprising the steps of:
- generating, by a first generating section, excitation light whose intensity is modulated with use of a carrier wave having at least one of a first frequency and a first phase;
- and which excites a phosphor, wherein the phosphor contains at least one selected from the group consisting of:
- an NV center of a diamond which NV center contains a nitrogen atom that substitutes for a carbon atom and a vacancy defect that is adjacent to the nitrogen atom;
- an SiV center of a diamond which SiV center contains a silicon atom that substitutes for a carbon atom and a vacancy defect that is adjacent to the silicon atom;
- a VSiVC center of a silicon carbide crystal which VSiVC center contains a vacancy defect that substitutes for a silicon atom and a vacancy defect that is adjacent to the vacancy defect;
- and a VSi center of a silicon carbide crystal which VSi center contains a vacancy defect that substitutes for a silicon atom;
- and
- generating, by a second generating section, at least one of a magnetic field or an electromagnetic wave which causes magnetic resonance so that intensity of fluorescence emitted from the phosphor is changed, wherein intensity of the magnetic field or intensity of the electromagnetic wave is modulated with use of a carrier wave having at least one of a second frequency differing from the first frequency and a second phase differing from the first phase.
5 more elements
Dependencies are inferred from the claim text.