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US 12,656,356 B2Granted
Pregabalin immunoassays
AssigneeARK Diagnostics, Inc.
InventorsJohnny Valdez, Byung Sook Moon, Alejandro A. Orozco, Gonzalo Naranjo
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Abstract
Compounds and methods for use in detecting pregabalin in a sample suspected of containing pregabalin are disclosed. Pregabalin derivatives are described for producing pregabalin conjugates. A pregabalin-immunogenic carrier conjugate may be used as an immunogen for the preparation of an anti-pregabalin antibody. A pregabalin-detectable label conjugate may be used in a signal producing system in pregabalin assays.
Claims30
A kit for detecting pregabalin in a sample, the kit comprising:
- a compound of Formula (A):
- wherein
- R1 or R2 is —X—W-L-Z, wherein
- when R1 is —X—W-L-Z, then R2 is —NH2,
- when R2 is —X—W-L-Z, then R1 is —OH, and
- X is NH;
- W is selected from a bond, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, and carbonyl;
- L is a bond or a linker;
- and
- Z is an enzyme;
- and
- instructions for an assay for detecting pregabalin.
9 more elements
A composition comprising compound of Formula (A):
- wherein
- R1 or R2 is —X—W-L-Z, wherein
- when R1 is —X—W-L-Z, then R2 is —NH2,
- when R2 is —X—W-L-Z, then R1 is —OH, and
- X is NH;
- W is selected from a bond, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, and carbonyl;
- L is a bond or a linker;
- and
- Z is an enzyme;
- and
- a sample suspected of containing pregabalin.
8 more elements
Dependencies are inferred from the claim text.