Methods for identifying and treating urinary tract infections

A method for treating a patient having a urinary tract infection, said method comprising the steps of

• identifying said patient having a urinary infection wherein said identification step comprises
• obtaining a urine sample from said patient;
• analyzing said urine sample for the presence of each of the proteins that have at least 95% sequence identity to a protein selected from the group consisting of B-cell lymphoma 6 protein (BCL6;
• SEQ ID NO:
• 23), C-X-C motif chemokine 6 (CXCL6), C-X-C motif chemokine 13 (CXCL13;
• SEQ ID NO:
• 29), cathepsin S (CTSS;
• SEQ ID NO:
• 24), heat shock 70 kDA protein 1A (HSPAIA;
• SEQ ID NO:
• 26), mitogen activated protein kinase 9 (MAPK9;
• SEQ ID NO:
• 25), protein E7 HPV18 (E7;
• SEQ ID NO:
• 30), and transgelin-2 (TAGLN2;
• SEQ ID NO:
• 31);
• wherein the presence of said one or more proteins identified a patient with a urinary tract infection;
• obtaining a reference level of each of the proteins having at least 95% sequence identity to a protein selected from the group consisting of B-cell lymphoma 6 protein (BCL6;
• SEQ ID NO:
• 23), C-X-C motif chemokine 6 (CXCL6), C-X-C motif chemokine 13 (CXCL13;
• SEQ ID NO:
• 29), cathepsin S (CTSS;
• SEQ ID NO:
• 24), heat shock 70 kDA protein 1A (HSPA1A;
• SEQ ID NO:
• 26), mitogen activated protein kinase 9 (MAPK9;
• SEQ ID NO:
• 25), protein E7 HPV18 (E7;
• SEQ ID NO:
• 30), and transgelin-2 (TAGLN2;
• SEQ ID NO:
• 31);
• determining the concentration of the corresponding proteins having at least 95% sequence identity to a protein selected from the group consisting of B-cell lymphoma 6 protein (BCL6;
• SEQ ID NO:
• 23), C-X-C motif chemokine 6 (CXCL6), C-X-C motif chemokine 13 (CXCL13;
• SEQ ID NO:
• 29), cathepsin S (CTSS;
• SEQ ID NO:
• 24), heat shock 70 kDA protein 1A (HSPAIA;
• SEQ ID NO:
• 26), mitogen activated protein kinase 9 (MAPK9;
• SEQ ID NO:
• 25), protein E7 HPV18 (Eb7;
• SEQ ID NO:
• 30), and transgelin-2 (TAGLN2;
• SEQ ID NO:
• 31) in said urine sample, wherein the concentration of each of said proteins in said urinary sample is determined and compared to said reference levels wherein a detected higher level of each of said proteins in said urine sample relative to the corresponding reference levels indicates the patient has a urinary tract infection;
• and
• treating said identified patient with antibiotics.