Anti-CD32A antibodies and their use for evaluating the presence of a viral reservoir
AssigneesCentre National De La Recherche Scientifique, Universite De Montpellier
InventorsMonsef Benkirane, Gaël Petitjean, Benjamin Descours
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Abstract
Monospecific anti-CD32a and bispecific anti-CD32a/CD3 antibodies and their use for evaluating the presence of a viral reservoir by quantifying the presence of lymphocyte cells expressions a CD32 and/or CD3 differentiation marker on their cell surface. Also, a method for the evaluation of the efficacy of a drug aiming to eradicate a cellular reservoir of mammalian cells infected with a mammalian immunodeficiency virus.
Claims4
An anti-CD32a antibody that does not recognize a CD32b marker, wherein the anti-CD32a antibody is a murine antibody comprising
- for the heavy chain, complementarity determining region (CDR) sequences as set forth in SEQ ID NOs:
- 44-46, and
- for the light chain, CDR sequences as set forth in SEQ ID NO:
- 49, KVA and SEQ ID NO:
- 50.
Dependencies are inferred from the claim text.