Clinical decision support system
AssigneeInstrumentation Laboratory Company
InventorsBenjamin Horev, Ethan Schonbrun, Gert Blankenstein, Luisa Andruzzi, Anne Winkler, Jacqueline Scott
Life of this patent
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Abstract
An example method includes: analyzing a clot curve for a test sample that is based on an assay performed on the test sample in order to obtain two or more parameters associated with the clot curve; analyzing the two or more parameters to determine at least one of (i) whether a fibrinogen concentration in the test sample is below a threshold, or (ii) whether there is a therapeutic or pharmaceutical anticoagulant present in the test sample; and outputting, to a user interface, information based on the determination.
Claims19
A system comprising:
- non-transitory machine-readable memory storing instructions that are executable;
- and
- one or more processing devices to execute the instructions to perform operations comprising:
- performing an analysis based on a clot curve for a test sample, the clot curve being based on an assay performed on the test sample, the analysis being performed in order to obtain one or more parameters associated with the clot curve, the one or more parameters being selected from a D′-parameter, a D″-parameter, or both the D′-parameter and the D″-parameter, wherein the D′ parameter is a difference in absorbance between time points of maximum acceleration and acceleration zero-crossing of the clot curve, and the D″-parameter is a difference in absorbance between time points of maximum acceleration and a threshold of an absorbance travel of the clot curve;
- analyzing the one or more parameters to determine at least one of (i) whether a fibrinogen concentration in the test sample is below a threshold, or (ii) whether there is a therapeutic or pharmaceutical anticoagulant present in the test sample;
- and
- outputting, on a user interface, information based on the determination.
A system comprising:
- non-transitory machine-readable memory storing instructions that are executable;
- and
- one or more processing devices to execute the instructions to perform operations comprising:
- obtaining a clot curve for a test sample based on an assay performed on the test sample;
- obtaining one or more parameters based on the clot curve by performing operations comprising;
- obtaining a second derivative of the clot curve;
- identifying a positive peak and a negative peak in the second derivative of the clot curve;
- identifying a first width of the negative peak and a second width of the positive peak;
- and
- determining a ratio of the first width to the second width;
- determining, based at least on the ratio whether a therapeutic or pharmaceutical anticoagulant is present in the test sample;
- and
- outputting, on a user interface, information based on the determination.
A method performed by one or more processing devices, the method comprising:
- performing an analysis based on a clot curve for a test sample, the clot curve being based on an assay performed on the test sample, the analysis being performed in order to obtain one or more parameters associated with the clot curve, the one or more parameters being selected from a D′-parameter, a D″-parameter, or both the D′-parameter and the D″-parameter, wherein the D′ parameter is a difference in absorbance between time points of maximum acceleration and acceleration zero-crossing of the clot curve, and the D″-parameter is a difference in absorbance between time points of maximum acceleration and a threshold of an absorbance travel of the clot curve;
- analyzing the one or more parameters to determine at least one of (i) whether a fibrinogen concentration in the test sample is below a threshold, or (ii) whether there is a therapeutic or pharmaceutical anticoagulant present in the test sample;
- and
- outputting, to a user interface, information based on the determination.
Dependencies are inferred from the claim text.