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AssigneesThe Broad Institute, Inc., Massachusetts Institute of Technology
InventorsXiao Wang, Jingyi Ren, Hu Zeng
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The present disclosure provides methods for profiling spatiotemporal gene expression, including methods for profiling spatiotemporal gene expression in vivo in a subject. The present disclosure also provides methods for profiling the role of post-transcriptional modification in spatiotemporal gene expression, methods for studying the role of spatiotemporal gene expression in the development or progression of a disease or disorder, methods for screening for an agent capable of modulating spatiotemporal gene expression, methods for diagnosing a disease or disorder in a subject, and methods for treating a disease or disorder in a subject. Oligonucleotide probes useful in the methods described herein are also provided by the present disclosure. The present disclosure also provide kits comprising the oligonucleotide probes disclosed herein. Systems for profiling spatiotemporal gene expression are also provided by the present disclosure.
A method for profiling spatiotemporal gene expression in a cell, the method comprising:
A plurality of oligonucleotide probes comprising a first oligonucleotide probe, a second oligonucleotide probe, and a third oligonucleotide probe, wherein
A system for profiling spatiotemporal gene expression in a cell comprising
Dependencies are inferred from the claim text.