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US 12,655,467 B2Granted
Methods for nucleic acid sequencing
AssigneeQuantum-Si Incorporated
InventorsJonathan M. Rothberg, Jeremy Lackey, Brian Reed, Xinghua Shi, Haidong Huang
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Abstract
Methods of sequencing molecules based on luminescence lifetimes and/or intensities are provided. In some aspects, methods of sequencing nucleic acids involve determining the luminescence lifetimes, and optionally luminescence intensities, of a series of luminescently labeled nucleotides incorporated during a nucleic acid sequencing reaction.
Claims13
A method of identifying a single molecule, the method comprising:
- exposing the single molecule to a plurality of luminescently labeled molecules;
- determining at least a luminescent lifetime of one or more luminescently labeled molecules during an interaction of at least one of the plurality of luminescently labeled molecules with the single molecule or with a complex comprising the single molecule;
- and
- identifying the single molecule based at least in part on the luminescent lifetime of the one or more luminescently labeled molecules;
- wherein the single molecule is a protein or a peptide.
2 more elements
Dependencies are inferred from the claim text.