Human chromosome 9 open reading frame 72 (C9ORF72) iRNA agent compositions and methods of use thereof

A double stranded ribonucleic acid (dsRNA) agent for inhibiting expression of C9orf72, or a salt thereof,

• wherein the dsRNA agent, or a salt thereof, comprises a sense strand and an antisense strand forming a double stranded region,
• wherein the sense strand and the antisense strand are each independently 17-25 nucleotides in length,
• wherein the antisense strand comprises at least 17 contiguous nucleotides from the nucleotide sequence 5′-AUUAAUCUUUAUCAGGUCUUUUC-3′ of SEQ ID NO:3,
• wherein all of the nucleotides of the sense strand and all of the nucleotides of the antisense strand independently comprise a nucleotide modification selected from the group consisting of a 2′-O-methyl nucleotide modification and a 2′-fluoro nucleotide modification,
• wherein the dsRNA agent, or a salt thereof, comprises 6-8 phosphorothioate internucleotide linkages;
• and
• wherein a lipophilic moiety containing a saturated or unsaturated C6-C18 hydrocarbon chain is conjugated to one or more internal positions selected from the group consisting of positions 4-8 and 13-18 on the sense strand, counting from the 5′-end of the strand.