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US 12,655,429 B2Granted
MicroRNA as a therapeutic agent
AssigneeCity of Hope
InventorsMarcin Tomasz Kortylewski, Guido Marcucci, Yu-Lin Su, Piotr Marek Swiderski
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Abstract
The disclosure provides, inter alia, hybridized nucleic acid sequences and compounds comprising Toll-like receptor 9-binding nucleic acid sequences and nucleic acid sequences comprising a microRNA passenger strand sequence hybridized to a microRNA guide strand sequence; pharmaceutical compositions comprising the hybridized nucleic acid sequences and compounds; and the use of the hybridized nucleic acid sequences, compounds, and pharmaceutical compositions to treat medical conditions, such as cancer and inflammatory diseases.
Claims21
A compound of Formula (I):
- (1) or Formula (II):
- R1-L1-R2 (I) or
- wherein:
- R1 is a CpG oligodeoxynucleotide (ODN);
- L1 and L2 are independently a linking group;
- R2 and R3 are independently a hybridized nucleic acid comprising a miR146a passenger strand hybridized to a miR146a guide strand;
- wherein the miR146a passenger strand has a sequence comprising SEQ ID NO:2, 3, 4, 5, 37, or 39, and the miR146a guide strand has a sequence comprising SEQ ID NO:7, 8, 36, or 38.
4 more elements
Dependencies are inferred from the claim text.