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US 12,655,415 B2Granted
Nanocaged enzymes with enhanced catalytic activity and increased stability
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsJinglin Fu, Zhao Zhao, Neal Woodbury, Hao Yan
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Abstract
The present disclosure describes a nanoparticle comprising a three dimensional DNA nanocage and a payload biological macromolecule, and methods of assembly thereof.
Claims15
A method of increasing the activity of an enzyme or antibody, the method comprising:
- trapping an enzyme or antibody in a first open half cage comprising M13 viral DNA;
- presenting a second open half cage which does not comprise an enzyme or antibody;
- assembling the first and second open half cages into a closed nanocage having an inner cavity and nanopores;
- wherein the inner cavity comprises the enzyme or antibody as a trapped enzyme or antibody respectively, and
- wherein the enzyme or antibody is less than 465 kDa in size.
2 more elements
Dependencies are inferred from the claim text.