US 12,655,412 B2Granted

Prephenate dehydratase variant and method of producing branched-chain amino acids using the same

AssigneeCj Cheiljedang Corporation

InventorsHayun Lee, Ju Eun Kim, Ji Hye Lee, Kyungrim Kim, Heeseok Lee

Life of this patent

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Provided is a prephenate dehydratase variant.

Dependent claims

A prephenate dehydratase variant, wherein an amino acid corresponding to position 182 from the N-terminus of the amino acid sequence of SEQ ID NO:

1 is substituted with an amino acid other than arginine, and wherein the prephenate dehydratase variant has 90% or more sequence identity to the amino acid sequence of SEQ ID NO:
1.

Dependencies are inferred from the claim text.

C12N 9/88
Enzymes; Proenzymes; Compositions thereof ; Processes for preparing, activating, inhibiting, separating or purifying enzymes: lyases
C12N 15/77
Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora: for Corynebacterium;…
C12P 13/06
Alpha- or beta- amino acids: alanine; Leucine; Isoleucine; Serine; Homoserine
C12P 13/08
Alpha- or beta- amino acids: lysine; Diaminopimelic acid; Threonine; Valine

From the US filing history. Foreign family members aren’t listed.

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