Virus-like particle
AssigneeAutolus Limited
InventorsAbigail Culshaw, Rosie Woodruff, Alexander Burkard, Martin Madill
Life of this patent
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Abstract
The present invention provides a virus-like particle (VLP) having a viral envelope which comprises: (i) a membrane protein comprising the extracellular domain of CD86; and (ii) a CD3-binding membrane protein. The VLP may be used to activate T cells prior to viral transduction.
Claims9
A virus-like particle (VLP) having a viral envelope which comprises:
- (i) a membrane protein comprising the extracellular domain of CD86 and the transmembrane domain of CD8, wherein the membrane protein comprises an amino acid sequence according to SEQ ID NO:
- 15;
- and
- (ii) a CD3-binding transmembrane protein.
A nucleic acid construct which comprises a first nucleic acid sequence encoding a membrane protein comprising the extracellular domain of CD86 and the transmembrane domain of CD8, wherein the membrane protein comprises an amino acid sequence according to SEQ ID NO:
- 15;
- and a second nucleic acid sequence encoding a CD3-binding transmembrane protein.
A kit of vectors which comprises:
- (i) a first vector which comprises a nucleic acid sequence encoding a membrane protein comprising the extracellular domain of CD86 and the transmembrane domain of CD8, wherein the membrane protein comprises an amino acid sequence according to SEQ ID NO:
- 15;
- and (ii) a second vector which comprises a nucleic acid sequence encoding a CD3-binding transmembrane protein.
Dependencies are inferred from the claim text.