Bioactive compound immobilization on sulfone polymers

A copolymer (P2) comprising:

• recurring units (RP2) of formula (M):
• recurring units (R*P2) of formula (Q):
• wherein
• each R1 is independently selected from the group consisting of a halogen, alkyl, alkenyl, alkynyl, aryl, ether, thioether, carboxylic acid, ester, amide, imide, alkali metal sulfonate, alkaline earth metal sulfonate, alkyl sulfonate, alkali metal phosphonate, alkaline earth metal phosphonate, alkyl phosphonate, amine and quaternary ammonium;
• each i is an integer independently selected from 0 to 4;
• T is selected from the group consisting of a bond, —CH2—;
• —O—;
• —SO2—;
• —S—;
• —C(O)—;
• —C(CH3)2—;
• —C(CF3)2—;
• —C(═CCl2)—;
• —C(CH3)(CH2CH2COOH)—;
• —N═N—;
• —RaC═CRb—, where each Ra and Rb, independently of one another, is a hydrogen or a C1-C12-alkyl, C1-C12-alkoxy, or C6-C18-aryl group;
• —(CF2)m—with m being an integer from 1 to 6;
• an aliphatic divalent group, linear or branched, of up to 6 carbon atoms;
• and combinations thereof;
• GQ is selected from the group consisting of at least one of the following formulae (GQ1), (GQ2), (GQ3), (GQ4), (GQ5), or (GQ6):
• wherein
• each k is an integer independently selected from 0 to 4;
• each j is an integer independently selected from 2 to 7;
• W is a bond, —C(CH3)2— or —SO2—;
• R2 is represented by the following formula:
• —(CH2)p—NRcB, with p being an integer selected from 1 to 5, with Rc being independently a C1-C6 alkyl or H, and with B representing a bioactive compound which is covalently and/or ionically bound to R2;
• and B being selected from the group consisting of:
• antithrombotic agents or derivatives thereof,
• amino acids,
• nucleic acids,
• glucuronic acid residues,
• hyaluronic acid or derivatives thereof,
• proteins,
• metal-chelating and/or protease inhibitor agents;
• acidic lipids,
• and
• any combinations of two or more compounds thereof.