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US 12,655,231 B2Granted
Native cell membrane nanoparticle and methods of use thereof
AssigneeVirginia Commonwealth University
InventorYouzhong Guo
Life of this patent
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Abstract
Provided are a Native Cell Membrane Nanoparticle (NCMN) system and methods of using the NCMN polymers to extract and/or purify one or more membrane proteins. The NCMN system includes at least one NCMN polymer and one or more membrane proteins in their native lipid bilayer membrane. A method of using the NCMN system to extract or isolate the one or more membrane proteins in the form of NCMN system without the use of a detergent while maintaining the protein's native structure and functional activity is provided.
Claims6
A Native Cell Membrane Nanoparticle (NCMN) system comprising:
- at least one NCMN polymer selected from the group of NCMN polymers 1-4 or combinations thereof,
- wherein the polymer 1 has the structure of Formula I;
- wherein the polymer 2 has the structure of Formula II;
- wherein the polymer 3 has the structure of formula III;
- and
- wherein the polymer 4 has the structure of formula IV
3 more elements
Dependencies are inferred from the claim text.