Neutralizing antibody for tooth regeneration treatment targeting USAG-1 molecule

An antibody or antigen-binding fragment thereof that specifically binds to and neutralizes USAG-1, the antibody or antigen-binding fragment thereof comprising:

• three heavy chain complementarity determining regions that comprise amino acid sequences set forth in SEQ ID NO:
• 15, SEQ ID NO:
• 16 and SEQ ID NO:
• 17 respectively, and three light chain complementarity determining regions that comprise amino acid sequences set forth in SEQ ID NO:
• 18, SEQ ID NO:
• 19 and SEQ ID NO:
• 20 respectively;
• three heavy chain complementarity determining regions that comprise amino acid sequences set forth in SEQ ID NO:
• 25, SEQ ID NO:
• 26 and SEQ ID NO:
• 27 respectively, and three light chain complementarity determining regions that comprise amino acid sequences set forth in SEQ ID NO:
• 28, SEQ ID NO:
• 29 and SEQ ID NO:
• 30 respectively;
• or
• three heavy chain complementarity determining regions that comprise amino acid sequences set forth in SEQ ID NO:
• 52, SEQ ID NO:
• 53 and SEQ ID NO:
• 54 respectively, and three light chain complementarity determining regions that comprise amino acid sequences set forth in SEQ ID NO:
• 55, SEQ ID NO:
• 56 and SEQ ID NO:
• 57 respectively.