Synthetic antibodies against VEGF and their uses

An isolated anti-VEGF antibody or antigen-binding portion thereof that specifically recognizes and binds a VEGF comprising CDRH 1-3 from a heavy chain fragment comprising the amino acid sequence:

• EVQLVESGGGLVQPGGSLRLSCAASGFDLFHYSIHWVRQAPGKGLEWVAYIYPS YGYTYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARHAWYYGWG LDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVD KKVEPKSCDKTHT of SEQ ID NO:
• 2 and CDRL1-3 from a light chain comprising the amino acid sequence:
• DIQMTQSPSSLSASVGDRVTITCRASQAAYGRVAWYQQKPGKAPKLLIYKASEL YAGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQRGWYLFTFGQGTKVEIKRT VAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESV TEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC of SEQ ID NO:
• 4;
• or
• CDRH 1-3 from a heavy chain fragment comprising the amino acid sequence:
• EVQLVESGGGLVQPGGSLRLSCAASGFDLDHYSIHWVRQAPGKGLEWVAYIYPS YGYTYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARHAWYYGWG LDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVD KKVEPKSCDKTHT of SEQ ID NO:
• 78 and CDRL1-3 from a light chain comprising the amino acid sequence:
• DIQMTQSPSSLSASVGDRVTITCRASQAAYGRVAWYQQKPGKAPKLLIYKASEL YAGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQRGWYLFTFGQGTKVEIKRT VAAPSVFIFPPSDSQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESV TEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC of SEQ ID NO:
• 76.