GRP78 targeted adoptive cell therapy
AssigneeSt. Jude Children's Research Hospital
InventorsMireya Paulina Velasquez, Stephen Gottschalk, Nikhil Hebbar, Rebecca Epperly, Abishek Vaidya
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Abstract
The present invention provides a chimeric antigen receptor (CAR) comprising an extracellular target-binding domain comprising at least one glucose-regulated-protein 78 (GRP78)-binding moiety. The present invention further provides polynucleotides and recombinant vectors encoding such CARs. The present invention further provides isolated host cells and methods for preparing isolated host cells expressing the CARs. The present invention further provides pharmaceutical compositions comprising the host cells and methods for treating a tumor using the pharmaceutical compositions.
Claims27
A polynucleotide encoding a chimeric antigen receptor (CAR) comprising
- a) an extracellular target-binding domain comprising one or more glucose-regulated-protein 78 (GRP78)-binding moieties, wherein the GRP78-binding moiety comprises the amino acid sequence of SEQ ID NO:
- 1;
- b) transmembrane domain;
- and
- c) a cytoplasmic domain comprising a signaling domain.
Dependencies are inferred from the claim text.