Methods and compositions for treating and/or preventing a disease or disorder associated with abnormal level and/or activity of the IFP35 family of proteins

A method of detecting autoimmune disease associated with abnormally high level and/or activity of Interferon-induced Protein 35 kD (IFP35) in a subject, wherein the method comprising:

• a) obtaining a biological sample from the subject, wherein the biological sample is selected from blood, plasma, serum, cerebrospinal fluid, synovial fluid, urine, sweat, tissue and organ samples from animals and plants and processed samples derived therefrom;
• and
• b) detecting the level and/or an activity of IFP35 with an antibody that specifically binds to a portion of a N1D domain, or one or more NID domains of IFP35 by immunodetection techniques, wherein the level is at least 10% higher than a level and/or an activity of IFP35 in a healthy control or exceeds 46±16 pg/mL;
• and
• c) administering to the subject having autoimmune disease associated with abnormally high level and/or activity of IFP35 an antibody or antigen-binding fragment that specifically binds to IFP35;
• wherein:
• 1) said immunodetection techniques comprise Enzyme-Linked Immunosorbent Assay (ELISA), Western blotting and Immunofluorescence Assay;
• 2) said autoimmune disease is Rheumatoid Arthritis, Systemic Lupus Erythematosus, Psoriasis, Inflammatory Bowel Disease, anti-NMDA receptor encephalitis, Multiple Sclerosis or Neuromyelitis Optica Spectrum Disorder (NMOSD);
• 3) said abnormally high level and/or activity is at least 10% higher than a level and/or activity in a healthy control or exceeds 46±16 pg/mL;
• said activity is the activity to binding to a cellular receptor or an antibody.