Klebicins for the control of Klebsiella
AssigneeNomad Bioscience GmbH
InventorsErna Denkovskiene, Audrius Misiunas, Aušra Ražanskiene
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Abstract
The invention provides a protein having cytotoxic activity against Klebsiella, said protein having a lipid II-cleaving activity or a pore-forming capability in a cell membrane of Klebsiella.
Claims3
A method of treating infection with Klebsiella of a subject in need thereof, comprising administering to said subject a protein having cytotoxic activity against Klebsiella or a composition comprising said protein, said protein comprising or consisting of an amino acid sequence comprising or consisting of the amino acid sequence of SEQ ID NO:
- 2 (KvarM), SEQ ID NO:
- 1 (KpneM), SEQ ID NO:
- 3 (KpneM2), or SEQ ID NO:
- 4 (KaerM).
A method of reducing infection or contamination of an object infected or contaminated with one or more Klebsiella species, comprising determining contamination of the object with Klebsiella and contacting said object with a protein having cytotoxic activity against Klebsiella, or with a composition comprising said protein, said protein comprising or consisting an amino acid sequence comprising or consisting of the amino acid sequence of SEQ ID NO:
- 2 (KvarM), SEQ ID NO:
- 1 (KpneM), SEQ ID NO:
- 3 (KpneM2), or SEQ ID NO:
- 4 (KaerM).
Dependencies are inferred from the claim text.