System and method for generating a protein sequence

A system comprising:

• at least one memory;
• and
• at least one processor coupled to the memory, and being configured for performing:
• receiving an empty or partially filled sequence of node elements, each node element of the sequence representing an amino acid position of the protein sequence and having an amino acid value chosen from one of a predetermined amino acid value and a missing value;
• receiving an edge index of edge elements, each edge element of the edge index being associated to a respective pair of the node elements and having at least a presence value, a positive presence value indicating the presence of a physical interaction between the amino acid positions corresponding to the pair of node elements, the edge index thereby defining a desired fold structure of the protein sequence;
• processing, by a computer-implemented neural network, a working copy of the partially filled sequence and the edge index to:
• determine, for each given edge element of the edge index having a positive presence value, an enhanced edge attribute value set based on the amino acid values of the pair of node elements of the working copy sequence associated to the given edge element;
• determine, for each given node element of the working copy sequence, an enhanced amino acid value based on the enhanced edge attribute value sets for every edge element having a positive presence value associated to the given node element;
• and
• for each given node element of the partially filled sequence having the missing value, determining a generated amino acid value based on the enhanced amino acid value corresponding to the given node element.