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US 12,655,175 B2Granted
C17, C20, and C21 substituted neuroactive steroids and their methods of use
AssigneeSage Therapeutics, Inc.
InventorsAlbert Jean Robichaud, Gabriel Martinez Botella, Boyd L. Harrison, Francesco G. Salituro, Andrew Griffin, Maria Jesus Blanco-Pillado
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Abstract
Described herein are neuroactive steroids or a pharmaceutically acceptable salt thereof. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. Also provided are pharmaceutical compositions comprising a compound described herein and methods of use and treatment, e.g., such as for inducing sedation and/or anesthesia.
Claims16
A compound of Formula (1-A):
- or a pharmaceutically acceptable salt thereof, wherein:
- R3 is alkyl, alkenyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl;
- one of RX and RY is aryl and the other is hydrogen or alkyl;
- R19 is hydrogen or alkyl;
- R5 is hydrogen;
- represents a single bond;
- and
- a is 1.
5 more elements
A compound of the Formula (III-b):
- or a pharmaceutically acceptable salt thereof, wherein:
- R3 is alkyl, alkenyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl;
- each of R2, R4, R6, R7, R11a, and R11b is independently hydrogen;
- Q is —N(RA1)(RA1);
- each instance of RA1 is independently hydrogen, alkyl, alkenyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl;
- R19 is —C(RC)2ORA1, wherein RC is hydrogen or alkyl;
- and
- represents a single bond and R5 is hydrogen.
5 more elements
A compound, or pharmaceutically acceptable salt thereof, selected from the group consisting of:
Dependencies are inferred from the claim text.