Solid forms of a nucleoside analogue and uses thereof
AssigneeGilead Sciences, Inc.
InventorsKassibla E. Dempah, Chiajen Lai
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Abstract
The present disclosure relates to solid forms (e.g. crystalline forms, solvates, and crystalline forms thereof) of a compound which is ((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl neopentyl carbonate, which is useful in the treatment of treating viral infections, for example paramyxoviridae, pneumoviridae, picornaviridae, flaviviridae, filoviridae, arenaviridae, orthomyxovirus, and coronaviridae infections.
Claims33
A solvate of a compound of Formula (I):
- wherein the solvate is an organic solvent solvate or hydrate.
A crystalline form of an ethanol solvate of a compound of Formula (I)
- wherein the crystalline form is characterized by an XRPD pattern comprising degree 20-reflections (±0.2 degrees 2θ) at 5.4°, 15.2°, and 23.8°.
A crystalline form of an acetonitrile solvate of a compound of Formula (I):
- wherein the crystalline form is characterized by an XRPD pattern comprising degree 2θ-reflections (±0.2 degrees 2θ) at 4.6°, 14.6°, and 18.3°.
A crystalline form of a compound of Formula (I)
- wherein the crystalline form is characterized by an XRPD pattern comprising degree 2θ-reflections (±0.2 degrees 2θ) at 5.3°, 18.7°, and 20.0°.
A crystalline form of a compound of Formula (I)
- wherein the crystalline form is characterized by an XRPD pattern comprising degree 2θ-reflections (±0.2 degrees 2θ) at 5.1°, 10.3°, and 15.2°.
A method of treating a viral infection in a human in need thereof, wherein the method comprises administering to the human a solvate of a compound of Formula (I) wherein the solvate is an organic solvent solvate or hydrate, a crystalline form of an ethanol solvate of a compound of Formula (I) wherein the crystalline form of the ethanol solvate is characterized by an XRPD pattern comprising degree 2θ-reflections (±0.2 degrees 2θ) at 5.4°, 15.2°, and 23.8°, a crystalline form of an acetonitrile solvate of a compound of Formula (I) wherein the crystalline form of the acetonitrile solvate is characterized by an XRPD pattern comprising degree 2θ-reflections (±0.2 degrees 2θ) at about 4.6°, 14.6°, and 18.3°, a crystalline form of a compound of Formula (I) characterized by an XRPD pattern comprising degree 2θ-reflections (±0.2 degrees 2θ) at 5.3°, 18.7°, and 20.0°, or a crystalline form of a compound of Formula (I) characterized by an XRPD pattern comprising degree 2θ-reflections (±0.2 degrees 2θ) at 5.1°, 10.3°, and 15.2°;
Dependencies are inferred from the claim text.