Compounds for activating invariant natural killer T-cells and methods of use in eliminating inflammatory senescent cells

A compound of formula DCD-(II):

• wherein:
• Z is selected from:
• wherein indicates the Z—O bond;
• wherein X is —NHCO— or oxygen;
• R1, R2, R3 and R4 are each independently selected from hydrogen, alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, and substituted heteroarylalkyl;
• X1, X2, X3, X4 and X5 are each independently selected from carbon, nitrogen, oxygen or sulfur;
• Ra is optionally absent or when present is selected from hydrogen or oxygen;
• wherein indicates a double or single bond;
• n is an integer from 2 to 25;
• Y is silicon;
• Rb, Rc and Rd are independently selected from hydrogen, alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, and substituted heteroarylalkyl, or
• Rc and Rd together with Y form a cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl group;
• and
• Re is alkyl or substituted alkyl,
• or salt, solvate or hydrate thereof.

A compound of formula DCD-(IA-1),

• wherein the compound of formula DCD-(IA-1) is:
• wherein:
• X is —NHCO— or oxygen
• R1, R2, R3 and R4 are each independently selected from hydrogen, alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, and substituted heteroarylalkyl;
• X1 and X2 are each independently selected from —C, —NRj, —O, —SRk, —Si, wherein Rj and Rk are each independently selected from hydrogen, alkyl or substituted alkyl, heteroalkyl, substituted heteroalkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, and substituted heteroarylalkyl;
• Ra is selected from hydrogen, oxygen, fluorine, —CF3, or together with X2 form a cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, and substituted heteroarylalkyl;
• wherein indicates a double or single bond;
• n is an integer from 2 to 25;
• Y is silicon;
• Rb, Rc and Rd are independently selected from hydrogen, alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, and substituted heteroarylalkyl, or
• Rc and Rd together with Y form a cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl group;
• and
• Re is alkyl or substituted alkyl,
• or salt, solvate or hydrate thereof;
• or salt, solvate or hydrate thereof.

A compound of formula DCD-(IIA-1),

• wherein the compound of formula DCD-(IIA-1) is:
• wherein X is —NHCO— or oxygen;
• R1, R2, R3 and R4 are each independently selected from hydrogen, alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, and substituted heteroarylalkyl;
• X1, X2, X3, X4 and X5 are each independently selected from carbon, nitrogen, oxygen or sulfur;
• Ra is optionally absent or when present is selected from hydrogen or oxygen;
• wherein indicates a double or single bond;
• n is an integer from 2 to 25;
• Y is silicon;
• Rb, Rc and Rd are independently selected from hydrogen, alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, and substituted heteroarylalkyl, or wherein Re and Rd together with Y form a cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl group;
• and
• Re is alkyl or substituted alkyl,
• or salt, solvate or hydrate thereof;
• or salt, solvate or hydrate thereof.