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US 12,655,158 B2Granted
Biomimetic G-quartet compounds
AssigneesCentre National De La Recherche Scientifique, Universite De Bourgogne
InventorsDavid Monchaud, Ibai Valverde, Pauline Lejault, Francesco Rota Sperti
Life of this patent
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Abstract
A compound of formula I: wherein A is present or absent; X1, X2, X3 and X4 are, independently from each other, an alkyl; Y1, Y2, Y3 and Y4 are independently from each other a C1-C10 alkyl, —Z1, Z2, Z3 and Z4 are independently from each other a C1-C5 linear alkyl; R1 is a group allowing to carry out bioorthogonal reactions; and R2 is group including a N.
Claims10
A compound of formula I:
- wherein
- A is Eu3+, Tb3+, Dy3+, or Yb3+;
- X1, X2 and X4 are, independently from each other a C1-C3 linear alkyl;
- X3 is a C2-C3 alkyl, substituted by R1;
- Y1, Y2, Y3 and Y4 are independently from each other a C1-C10 alkyl, saturated or not, substituted or not by an acid group, possibly with a substitution of at least one carbon atom by N, P, a phenyl, a C═O group, phosphonate group, or a triazole group;
- Z1, Z2, Z3 and Z4 are independently from each other a C1-C5 linear alkyl;
- R1 is (CH2)p-L-T, wherein
- p varies from 0 to 5;
- and
- L is a linear or branched, saturated or not, C1-C12 alkyl, possibly with a substitution of at least one carbon by:
- a C═O group or an heteroatom, an aryl group possibly substituted, a triazole group, or a diazirin group;
- T is a group allowing to carry out bioorthogonal reactions, in particular the following groups:
- azide, tetrazine substituted or not, alkyne, constrained alkyne, constrained cycloalkenes, and
- R2 is (CH2)m-NHRx, wherein m varies from 1 to 4 and Rx is H or a protecting group, or a guanidinium group,
- or a salt or a solvate thereof.
12 more elements
Dependencies are inferred from the claim text.