4-(imidazo[1,2-a]pyridin-3-yl)-pyrimidine
AssigneeMerck Patent GmbH
InventorsDieter Dorsch, Andreas Blum, Hans-Peter Buchstaller
Life of this patent
Estimating the term…
Abstract
Compounds of the formula I are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer. R1 denotes H, Hal, CF3, NO2, A, [C(R3)2]nN(R3)2, [C(R3)2]nHet1, OR3, O[C(R3)2]nN(R3)2, O[C(R3)2]nS(O)mR3, O[C(R3)2]nCOOR3, O[C(R3)2]nCOON(R3)2, O[C(R3)2]nHet1, O[C(R3)2]nN(R3)Het1, O[C(R3)2]nPh, or O[C(R3)2]nCyc. R2 denotes H or CH3. R3 denotes H or A. V denotes H or Hal. X denotes O or N(R3). Y denotes phenylene, pyridin-diyl, thiophen-diyl, 1,3-thiazol-diyl or pyrazol-diyl, each of which is unsubstituted or mono-, di- or trisubstituted by Hal and/or A. Z denotes CON(R3)2, phenyl, Het4 or —O-A.
Claims8
A compound A75 which is [4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-{6-[7-(3-pyrrolidin-1-yl-propoxy)-imidazo[1,2-a]pyridin-3-yl]-pyrimidin-4-yl}-amine of the following formula
- and/or a pharmaceutically acceptable salt, tautomer, and/or stereoisomer thereof.
A compound A75 which is [4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-{6-[7-(3-pyrrolidin-1-yl-propoxy)-imidazo[1,2-a]pyridin-3-yl]-pyrimidin-4-yl}-amine of the following formula
A pharmaceutically acceptable salt of a compound A75,
- wherein A75 is [4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-{6-[7-(3-pyrrolidin-1-yl-propoxy)-imidazo[1,2-a]pyridin-3-yl]-pyrimidin-4-yl}-amine of the following formula
A medicament, comprising:
- at least a compound A75 which is [4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-{6-[7-(3-pyrrolidin-1-yl-propoxy)-imidazo[1,2-a]pyridin-3-yl]-pyrimidin-4-yl}-amine of the following formula
- and/or
- a pharmaceutically acceptable salt, tautomer, and/or stereoisomer thereof, and
- optionally, a pharmaceutically acceptable carrier, excipient, and/or vehicle.
A medicament, comprising:
- at least a compound A75 which is [4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-{6-[7-(3-pyrrolidin-1-yl-propoxy)-imidazo[1,2-a]pyridin-3-yl]-pyrimidin-4-yl}-amine of the following formula
- and
- optionally, a pharmaceutically acceptable carrier, excipient, and/or vehicle.
Dependencies are inferred from the claim text.