Compounds with ALK inhibitory activity and preparation method and use thereof
AssigneeCgenetech (Suzhou, China) Co., Ltd.
InventorsTong Wang, Yong Zheng, Yongsheng Wang, Qin Lu, Huiping Pan, Qiang Yu, Juping Ding, Yan Hao
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Abstract
The present application relates to the technical field of pharmaceutical chemistry, and particularly relates to compounds with ALK inhibitory activity and preparation method and use thereof. The compounds with ALK inhibitory activity provided by the present application are ALK inhibitors for treating diseases responsive to the inhibition of ALK kinase, can be used for treating ALK-positive diseases, such as tumors and cancers, and have broad application prospects.
Claims14
A compound shown in formula (I) or a pharmaceutically acceptable salt thereof:
- wherein, R1 is selected from hydrogen, substituted or unsubstituted C1-C4 alkyl, C3-C6 cycloalkyl, substituted or unsubstituted aryl or heterocyclic aryl, and halogen;
- R2 is selected from hydrogen, substituted or unsubstituted C1-C4 alkyl, cyano, and halogen;
- the substituent of C1-C4 alkyl is selected from C3-C6 cycloalkyl, halogen, and cyano;
- R3 is selected from heterocyclic aryl, aryl, and substituted or unsubstituted 5-7 membered heterocycle, wherein the 5-7 membered heterocycle contains 1-3 heteroatoms that are each independently selected from N, P, O, and S;
- R4 and R5 are each independently selected from hydrogen, substituted or unsubstituted saturated C1-C4 alkyl, and substituted or unsubstituted unsaturated C1-C4 alkyl.
Dependencies are inferred from the claim text.