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US 12,655,108 B2Granted
Heterocyclic compound as TYK2 pseudokinase domain inhibitor, synthetic method, and use
AssigneeZhejiang Wenda Pharma Technology Ltd.
InventorNenghui Wang
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Abstract
The present invention provides a heterocyclic compound as a TYK2 pseudokinase (JH2) domain inhibitor, a synthetic method, and use. In particular, the present invention provides a heterocyclic compound as represented by formula I, or a pharmaceutically acceptable salt thereof, wherein groups are as defined in the text. The heterocyclic compound in the present invention has excellent TYK2 (JH2) selective inhibitory activity.
Claims10
A heterocyclic compound or pharmaceutically acceptable salts thereof, wherein the compound is as represented by formula I;
- wherein,
- X and Y are each independently CR5 or N;
- Z is CR6 or N;
- W1 and W2 are each independently divalent group selected from the group consisting of O, S, SO2, CO, NR7CO, CONR7;
- W3 is a divalent group selected from the group consisting of CO, NR7, NR7CO, CONR7;
- R3 is substituted or unsubstituted C3-6 cycloalkyl;
- R4 is selected from the group consisting of substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C3-6 cycloalkyl;
- and R4 is optionally further substituted with R1 and R2;
- R1 and R2 are each independently selected from the group consisting of H, substituted or unsubstituted C1-6 alkyl;
- or, R1 and R2 together with the carbon to which they are attached form substituted or unsubstituted C3-6 cycloalkyl;
- R5, R6 and R7 are each independently selected from the group consisting of H, substituted or unsubstituted C1-4alkyl;
- n=1 or 2;
- unless otherwise specified, said substituted means that one or more of hydrogen atoms in the group are substituted with substituents selected from the group consisting of halogen, C1-4 alkyl, and C1-4 haloalkyl.
10 more elements
Dependencies are inferred from the claim text.