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US 12,655,106 B2Granted
HDAC6 inhibitors and uses thereof
AssigneeEikonizo Therapeutics, Inc.
InventorsFlorence Fevrier Wagner, Dean Hickman
Life of this patent
Estimating the term…
Abstract
Provided herein are compounds that selectively inhibit HDAC6, a protein whose activity is associated with a variety of diseases (e.g., cancer, neurological disorders). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HDAC6-related diseases and disorders (e.g., Alzheimer's disease, cancer) with the compounds in a subject, by administering the compounds and/or compositions described herein.
Claims20
A compound of Formula (II):
- or a pharmaceutically acceptable salt thereof, wherein:
- X1 is hydrogen;
- X2 is fluoro;
- Y1 is CRx;
- A is a 3-6 membered monocyclic cycloalkyl or heterocyclyl, a 5-10 membered bridged cycloalkyl or bridged heterocyclyl, or a 7-10 membered spirocyclic ring system optionally comprising a heterocycle;
- each R1 is hydrogen;
- each R2 is hydrogen;
- Rx is hydrogen;
- Ra is hydrogen;
- Rb is unsubstituted C1-4 alkyl;
- Rc is hydrogen;
- and
- n is 0 or 1.
10 more elements
A compound of Formula (II):
- or a pharmaceutically acceptable salt thereof, wherein:
- X1 is hydrogen;
- X2 is fluoro;
- Y1 is CRx;
- A is a 4-6 membered monocyclic cycloalkyl or heterocyclyl, a 5-10 membered bridged cycloalkyl or bridged heterocyclyl, or a 7-10 membered spirocyclic ring system optionally comprising a heterocycle;
- each R1 is hydrogen;
- each R2 is hydrogen;
- Rx is hydrogen;
- Ra is hydrogen;
- Rb is unsubstituted ethyl;
- Rc is hydrogen;
- and
- n is 1.
10 more elements
A compound of Formula (II):
- or a pharmaceutically acceptable salt thereof, wherein:
- X1 is hydrogen;
- X2 is fluoro;
- Y1 is CRx;
- A is a 4-6 membered monocyclic cycloalkyl or heterocyclyl comprising an oxygen heteroatom, or a 7-10 membered spirocyclic ring system optionally comprising a heterocycle comprising an oxygen heteroatom;
- each R1 is hydrogen;
- each R2 is hydrogen;
- Rx is hydrogen;
- Ra is hydrogen;
- Rb is unsubstituted ethyl;
- Rc is hydrogen;
- and
- n is 1.
10 more elements
Dependencies are inferred from the claim text.