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US 12,655,091 B2Granted
N-benzyl-alpha-aminoamides as anaphase-promoting complex/cyclosome (APC/C) inhibitors
AssigneesConsejo Superior De Investigaciones Cientificas (Csic), Oxford Brookes University
InventorsAgatha Bastida Codina, Raúl Benito Arenas, Victor M. Bolanos-García, Natalie Laura Curtis
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Abstract
The invention relates to a compound of formula I which are inhibitors of anaphase promoting complex/cyclosome (APC/C) function of formula I, wherein the meaning for R1 and R2 is as disclosed in the description. These compounds are useful in the treatment of cancer, particularly, in the treatment of breast cancer.
Claims10
A compound of formula I:
- or a pharmaceutical salt thereof, wherein:
- R1 represents —CF3;
- R2 represents C1-C6 alkyl substituted Cy1;
- Cy1 represents a phenyl group (-Ph) substituted by —OH.
1 more element
A method for the treatment of cancer comprising administering to a subject in need thereof an effective amount of a compound of formula I:
- or a pharmaceutical salt thereof, wherein:
- R1 represents —CF3;
- R2 represents C1-C6 alkyl substituted Cy1;
- Cy1 represents a phenyl group (-Ph) substituted by —OH,
- and wherein the cancer is breast cancer.
2 more elements
Dependencies are inferred from the claim text.