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US 12,654,167 B2Granted
Perfusable hydrogel microchannel shell and methods thereof
AssigneeUniversity of Virginia Patent Foundation
InventorsNathan Swami, Walter Varhue, George Christ, Shayn Peirce-Cottler, Aditya Rane
Life of this patent
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Abstract
A microfluidic device can include a superstructure defining a microfluidic channel therein and a first hydrogel bonded to the microfluidic channel to define a perfusable channel therein, the first hydrogel including cells embedded therein or thereon. The microfluidic device can optionally include a second hydrogel bonded to the microfluidic channel or to the hydrogel.
Claims20
A microfluidic device comprising:
- a superstructure defining a microfluidic channel therein;
- and
- a first hydrogel releasably bonded to all sides of the microfluidic channel to define a perfusable channel therein, the first hydrogel including cells embedded therein, the first hydrogel patterned to mimic organic tissue.
A method of forming a hydrogel microfluidic perfusable channel, the method comprising:
- providing a microchannel in a superstructure;
- forming a channel imprint;
- aligning the channel imprint with the microchannel of the superstructure;
- bonding, releasably, the channel imprint to the superstructure;
- bonding, a first hydrogel to the channel imprint and the microchannel of the superstructure form a perfusable channel in the first hydrogel;
- de-bonding the channel imprint from the first hydrogel and the superstructure;
- and
- removing the channel imprint from the superstructure.
5 more elements
A microfluidic device comprising:
- a superstructure defining a microfluidic channel therein;
- a first hydrogel releasably bonded to all sides of the microfluidic channel to define a perfusable channel therein, the first hydrogel including cells embedded therein;
- and
- a second hydrogel bonded to the first hydrogel to define, together with the first hydrogel, the perfusable channel.
1 more element
Dependencies are inferred from the claim text.