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US 12,654,163 B2Granted
Viral infections—treatment with convalescent plasma/serum
AssigneeRegen Lab USA LLC
InventorsAntoine Turzi, Andreas Pigni, Farid Gomri, Hosni Trabelsi
Life of this patent
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Abstract
A container for use in the treatment and/or prophylaxis of viral infections and/or associated conditions prefilled with a thixotropic gel characterized by a density selected from about 1.02 g/cm3 to about 1.05 g/cm3.
Claims8
A container configured that is:
- (i) prefilled with at the least a thixotropic gel characterized by a density selected from about 1.02 g/cm3 to about 1.05 g/cm3, wherein said container is prefilled only with said thixotropic gel as layer from the distal end of said container, or
- (ii) prefilled only with:
- a) a thixotropic gel characterized by a density selected from about 1.02 g/cm3 to about 1.05 g/cm3, and
- b) an anticoagulant,
- wherein said thixotropic gel is the first layer from the distal end of said container, followed by a second layer consisting of said anticoagulant, and
- wherein said anticoagulant comprises sodium citrate, or
- (iii) prefilled only with:
- a) a thixotropic gel characterized by a density selected from about 1.02 g/cm3 to about 1.05 g/cm3, and
- b) a coagulation activator,
- wherein said thixotropic gel is the first layer from the distal end of said container, followed by a second layer consisting of said coagulation activator,
- wherein said coagulation activator comprises calcium gluconate,
- wherein said thixotropic gel is selected among an oligomer, polymer, polyolefin hydrocarbon oligomer, an acrylic resin mixture, a PEG-Silica Gel or any combination thereof, and in which the thixotropic gel is selected from:
- a polyoxyalkylene polyol, trioctyl trimellitate, a hydrocarbonated resin, silica dimethyl silylate, or any combination thereof, and
- wherein the polyoxyalkylene polyol is selected from:
- polyethylene and/or polypropylene glycol trimethylolpropane ether, methyloxirane polymer with oxirane, ether with 2-ethyl-2-(hydroxymethyl)-1, 3-propanediol;
- poly (oxyethylene and/or oxypropylene) trimethylolpropane ether, trimethylol propane, ethoxylated trimethylolpropane, propxylated trimethylol propane, or any combination thereof.
13 more elements
A container configured to be that is:
- (i) prefilled with at the least a thixotropic gel characterized by a density selected from about 1.02 g/cm3 to about 1.05 g/cm3, wherein said container is prefilled only with said thixotropic gel as layer from the distal end of said container, or
- (ii) prefilled only with:
- a) a thixotropic gel characterized by a density selected from about 1.02 g/cm3 to about 1.05 g/cm3, and
- b) an anticoagulant,
- wherein said thixotropic gel is the first layer from the distal end of said container, followed by a second layer consisting of said anticoagulant, and
- wherein said anticoagulant comprises sodium citrate, or
- (iii) prefilled only with:
- a) a thixotropic gel characterized by a density selected from about 1.02 g/cm3 to about 1.05 g/cm3, and
- b) a coagulation activator,
- wherein said thixotropic gel is the first layer from the distal end of said container, followed by a second layer consisting of said coagulation activator,
- wherein said coagulation activator comprises calcium gluconate, and
- wherein said thixotropic gel comprises trioctyl trimellitate, silica, hydrocarbon resin, polyol, phenol(s) and phosphite ester.
9 more elements
A container that is:
- (i) prefilled with at the least a thixotropic gel characterized by a density selected from about 1.02 g/cm3 to about 1.05 g/cm3, wherein said container is prefilled only with said thixotropic gel as layer from the distal end of said container, or
- (ii) prefilled only with:
- a) a thixotropic gel characterized by a density selected from about 1.02 g/cm3 to about 1.05 g/cm3, and
- b) an optional anticoagulant,
- wherein said thixotropic gel is the first layer from the distal end of said container, followed by a second layer consisting of said anticoagulant, and
- wherein said anticoagulant comprises sodium citrate, or
- (iii) prefilled only with:
- a) a thixotropic gel characterized by a density selected from about 1.02 g/cm3 to about 1.05 g/cm3, and
- b) a coagulation activator,
- wherein said thixotropic gel is the first layer from the distal end of said container, followed by a second layer consisting of said coagulation activator,
- wherein said coagulation activator comprises calcium gluconate, and
- wherein said thixotropic gel comprises trioctyl trimellitate, silica, hydrocarbon resin, azelate ester and phosphite ester, wherein said trioctyl trimellitate is Tris (2 ethyhexyl), said silica is Dimethtyl dichlorosilane, said hydrocarbon resin is Cycloaliphatic hydrocarbon Resin, said azelate esters is Azelate de bis (2-ethylhexyle), and said phenol(s) is Tetrakis (3-(3, 5-di-tert-butyl-4-hydroxyphenyl) propionate of pentaerythritol).
9 more elements
Dependencies are inferred from the claim text.