Chiral bimetallic cooperative catalysis system containing chelating ligand and use thereof in asymmetric synthesis of bedaquiline

A bimetallic cooperative catalysis system for synthesis of (1R,2S)-bedaquiline, wherein a bimetal comprises n-butyl lithium and another lithium salt, and the bimetallic cooperative catalysis system comprises a chelating ligand;

• the chelating ligand is formed by lithium amide and chiral lithium aminoalcohol, the lithium amide is generated by an achiral secondary amine and the n-butyl lithium, and the chiral lithium aminoalcohol is in-situ generated by amino alcohol and the n-butyl lithium;
• or the chelating ligand is formed by lithium diisopropylamide, an achiral secondary amine, and lithium aminoalcohol, and the chiral lithium aminoalcohol is in-situ generated by amino alcohol and the n-butyl lithium;
• and
• wherein the amino alcohol is (1S,2R)-2-amino-1,2-diphenylethanol.