Monodispersed microbubbles production using a modified micro-venturi bubble generator

A method of producing monodisperse microbubbles, the method comprising:

• providing a microfluidic device including a first microfluidic channel including a convergent section and a constant-width section downstream from the convergent section, a second microfluidic channel including an orthogonal section oriented orthogonal to the constant-width section, and a third microfluidic channel including a divergent section, wherein the constant-width section and the orthogonal section discharge into a junction, wherein the junction discharges into the divergent section, and wherein the constant-width section has a hydraulic diameter of no greater than about 1 mm;
• supplying a flow of a continuous phase fluid through at least the divergent section and the constant-width section of the first microfluidic channel into the junction;
• and
• supplying a flow of a dispersed phase fluid through at least the orthogonal section of the second microfluidic channel into the junction to produce one or more monodisperse microbubbles.