Memory enhancement by prefrontal deep brain stimulation synchronized to medial temporal lobe during sleep
AssigneesThe Regents of the University of California, Ramot at Tel-Aviv University Ltd.
InventorsItzhak Fried, Yuval Nir, Maya Geva-Sagiv
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Abstract
A closed-loop neuromodulatory system comprises one or more processors and memory. The system is configured to record signals from a first region of a brain of a human subject during sleep via a first electrode. The system is configured to determine, from the recorded signals, active periods of the first region. The system is configured to stimulate a second region of the brain, different from the first region, during the active periods via a second electrode that is electrically coupled to the first electrode via closed-loop control.
Claims20
A closed-loop neuromodulatory system, comprising:
- one or more processors;
- and
- memory storing instructions for execution by the one or more processors, the stored instructions including instructions for:
- recording signals from a first region of a brain of a human subject during sleep via a first electrode;
- determining, from the recorded signals, slow-wave activity periods of the first region;
- and
- applying, in real-time via a second electrode that is electrically coupled to the first electrode via closed-loop control, one or more electrical stimulations to a second region of the brain, wherein the second region of the brain is different from the first region of the brain, and the applying includes time-locking the one or more electrical stimulations with the slow-wave activity periods of the first region.
A method, comprising:
- recording signals from a first region of a brain of a human subject during sleep via a first electrode;
- determining, from the recorded signals, slow-wave activity periods of the first region;
- and
- applying, in real-time via a second electrode that is electrically coupled to the first electrode via closed-loop control, one or more electrical stimulations to a second region of the brain, wherein the second region of the brain is different from the first region of the brain, and the applying includes time-locking the one or more electrical stimulations with the slow-wave activity periods of the first region.
A non-transitory computer-readable storage medium having instructions stored thereon, which when executed by one or more processors, cause the processors to perform operations comprising:
- recording signals from a first region of a brain of a human subject during sleep via a first electrode;
- determining, from the recorded signals, slow-wave activity periods of the first region;
- and
- applying, in real-time via a second electrode that is electrically coupled to the first electrode via closed-loop control, one or more electrical stimulations to a second region of the brain, wherein the second region of the brain is different from the first region of the brain, and the applying includes time-locking the one or more electrical stimulations with the slow-wave activity periods of the first region.
Dependencies are inferred from the claim text.