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US 12,653,992 B2Granted
Methods and devices for treating a disease with biotherapeutics
AssigneeBT Bidco, Inc.
InventorsJeffrey A. Shimizu, Mitchell Lawrence Jones, Mark Sasha Drlik, Iman Niknia, Nathan John Muller, Tuyen Nguyen, Christopher Loren Wahl, Edward Mudge, Nicholas Mark Salt, Nia Eleri Stevens, Stuart Robert Abercrombie, Christopher Ian Bunce, Nelson Quintana
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Abstract
This disclosure features methods and devices for treating diseases with orally-delivered biotherapeutics.
Claims18
An ingestible device comprising:
- a storage reservoir in a housing;
- a dispensable substance in the storage reservoir;
- one or more nozzles in the housing connecting into the storage reservoir, each nozzle extending through a curved sidewall of the housing;
- a gas container in the housing containing a compressed gas providing an internal pressure of about 280 psig to about 390 psig;
- and
- a piercer for piercing the gas container to release the compressed gas from the gas container the piercer exerting a force on an enteric material triggering component, the enteric material triggering component resisting the force until the device is triggered, releasing the compressed gas from the gas container after the ingestible device is ingested;
- wherein the released compressed gas drives the dispensable substance into the submucosa of the gastrointestinal tract of a patient.
4 more elements
An ingestible device comprising:
- a storage reservoir in a housing;
- a dispensable substance in the storage reservoir;
- one or more nozzles connecting into the storage reservoir, each nozzle extending through a sidewall of the housing;
- a gas container in the housing containing a compressed gas, the gas container configured to provide an internal pressure of about 280 psig to about 390 psig;
- a sliding piston in the housing between the gas container and the storage reservoir;
- and
- an enteric material triggering component which triggers release of the compressed gas from the gas container after the ingestible device is ingested;
- wherein the internal pressure is configured to deliver the dispensable substance into the submucosa of the gastrointestinal tract of a patient.
5 more elements
Dependencies are inferred from the claim text.