System and method for controlling oxygen-enrichment therapy based on microvascular resistance feedback
AssigneeZoll Circulation, Inc.
InventorsJeffrey Lance Creech, Stephen Elwood Myrick, Richard A. Helkowski, Fred Shen, Ramu Perumal, Gary A. Freeman
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Abstract
The present disclosure provides systems and methods for controlling gas-enrichment, e.g., oxygen-enrichment, therapy. One or more sensors and/or one or more imaging systems may be used to measure or determine one or more physiological parameters of the patient. Feedback regarding one or more physiological parameters or microvascular resistance may be provided for titrating or controlling the gas-enrichment therapy.
Claims22
A system for controlling gas-enrichment therapy in a patient, the system comprising:
- a gas-enrichment system configured to enrich a liquid with gas to form a gas-enriched liquid and to mix the gas-enriched liquid with blood to form gas-enriched blood;
- a plurality of conduits fluidly coupled to the gas-enrichment system, a first conduit of the plurality of conduits configured for flow of the blood from the patient to the gas-enrichment system, and a second conduit of the plurality of conduits configured for flow of the gas-enriched blood from the gas-enrichment system to the patient;
- a pump coupled to at least one conduit of the plurality of conduits, the pump configured to pump blood to and from the gas-enrichment system and the patient;
- a wire configured to extend into a vasculature of the patient and comprising at least one pressure sensor configured to measure a blood pressure in the vasculature of the patient, the blood pressure indicative of a microvascular resistance in the vasculature of the patient;
- and
- a controller comprising a processor, a memory, and associated circuitry communicatively coupled to the pressure sensor, wherein the processor is configured to perform operations comprising:
- receiving one or more signals corresponding to a measured blood pressure from the at least one pressure sensor;
- estimating, based on the measured blood pressure, a microvascular resistance in the vasculature of the patient;
- and
- generating, based on the estimated microvascular resistance in the vasculature of the patient, an alert or control signal for controlling an amount of the gas-enriched blood delivered to the patient.
A system for controlling gas-enrichment therapy in a patient, the system comprising:
- a gas-enrichment system configured to enrich a liquid with gas to form a gas-enriched liquid and to deliver the gas-enriched liquid into a vasculature of the patient to form gas-enriched blood;
- at least one conduit fluidly coupled to the gas-enrichment system, the at least one conduit configured for flow of the gas-enriched liquid from the gas-enrichment system to the patient;
- a pump coupled to the at least one conduit, the pump configured to pump gas-enriched liquid from the gas-enrichment system to the patient;
- a wire configured to extend into a vasculature of the patient and comprising at least one pressure sensor configured to measure a blood pressure in the vasculature of the patient, the blood pressure indicative of a microvascular resistance in the vasculature of the patient;
- and
- a controller comprising a processor, a memory, and associated circuitry communicatively coupled to the pressure sensor, wherein the processor is configured to perform operations comprising:
- receiving one or more signals corresponding to a measured blood pressure from the at least one pressure sensor;
- estimating, based on the measured blood pressure, the microvascular resistance in the vasculature of the patient;
- and
- generating, based on the microvascular resistance in the vasculature of the patient, an alert or control signal for titrating or controlling an amount of the gas-enriched liquid delivered to the patient.
Dependencies are inferred from the claim text.