Compounds for fast and efficient click release

A compound satisfying Formula (19):

• and pharmaceutically acceptable salts thereof, wherein:
• X1, X2, X4, and X5, are independently C(R47)2 or CR47YT1;
• X3 is C(R47)2, CR47YT1, or YT3;
• wherein at least one of conditions (a)-(b) is met:
• (a) at least one of X1, X2, X3, X4, X5, is CR47YT1;
• YT1 is positioned cis relative to Ha;
• YT1 is selected from the group consisting of OH, SH, and N(R38)2;
• and
• (b) X3 is YT3;
• YT3 is NR38 and is not flanked by C(O), C(S), S(O), or S(O)2;
• R48 is selected from the group consisting of —OC(O)—(SP)kCA, —OC(S)—(SP)kCA, —SC(O)(SP)kCA, —SC(S)—(SP)kCA, —O-(LC((SP)kCA)s((SP)kCA)s((SP)i—CB)j)r—(SP)kCA, —S-(LC((SP)kCA)s((SP)kCA)s((SP)i—CB)j)r—(SP)kCA, and —(SP)kCA;
• r is an integer in range of from 0 to 2;
• each s is independently 0 or 1;
• each i is independently an integer in a range of from 0 to 4;
• j is an integer in range of from 0 to 4;
• each k is independently 0 or 1;
• LC is a self-immolative linker and S′ is a spacer;
• each CA and CB are independently selected from the group consisting of organic molecules and inorganic molecules;
• wherein, when R48 is —OC(O)—(SP)kCA, —OC(S)—(SP)kCA, —SC(O)—(SP)kCA, or
• —SC(S)—(SP)kCA, then SP˜, when k>0, or CA, when k=0, is bound to the —OC(O)—,
• —OC(S)—, —SC(O)—, or —SC(S)— of R48 via an atom selected from the group consisting of O, C, S, and N, wherein this atom is part of SP or CA,
• wherein, when R48 is —O-(LC((SP)kCA)s((SP)kCA)s((SP)i—CB)j)r—(SP)kCA or
• —S-(LC((SP)kCA)s((SP)kCA)s((SP)i—CB)j)r—(SP)kCA and r is 0, then SP, when k>0, or CA, when k=0, is bound to the —O— or —S— moiety of R48 on the allylic position of the trans-cyclooctene ring of Formula (19) via a group selected from the group consisting of —C(O)—, and —C(S)—, wherein this group is part of SP or CA,
• wherein, when R48 is —O-(LC((SP)kCA)s((SP)kCA)s((SP)i—CB)j)r—(SP)kCA or
• —S-(LC((SP)kCA)s((SP)kCA)s((SP)i—CB)j)r—(SP)kCA and r is 1, then LC is bound to the —O— or —S— moiety on the allylic position of the trans-cyclooctene ring of Formula (19) via a group selected from the group consisting of —C(YC2)YC1—, and a carbon atom, wherein this group is part of LC;
• wherein YC1 is selected from the group consisting of —O—, —S—, and —NR36—,
• wherein YC2 is selected from the group consisting of O and S,
• wherein, when R48 is —O-(LC((SP)kCA)s((SP)kCA)s((SP)i—CB)j)r—(SP)kCA or —S-(LC((SP)kCA)s((SP)kCA)s((SP)i—CB)j)r—(SP)kCA and r is 1, then SP, when k>0, or CA, when k=0, is bound to LC via a moiety selected from the group consisting of —O—, —S—, and —N—, wherein said moiety is part of SP or CA, wherein, when R48 is —(SP)kCA, then SP, when k>0, or CA, when k=0, is bound to the allylic position of the trans-cyclooctene of Formula (19) via an —O— or an —S— atom, wherein this atom is part of SP or CA,
• wherein each R37 and R36 is independently selected from the group consisting of hydrogen, —(SP)i—CB with i independently being an integer in a range of from 0 to 4, C1-C24 alkyl groups, C2-C24 alkenyl groups, C2-C24 alkynyl groups, C6-C24 aryl groups, C2-C24 heteroaryl groups, C3-C24 cycloalkyl groups, C5-C24 cycloalkenyl groups, C12-C24 cycloalkynyl groups, C3-C24 (cyclo)alkyl(hetero)aryl groups, C3-C24 (hetero)aryl(cyclo)alkyl, C4-C24 (cyclo)alkenyl(hetero)aryl groups, C4-C24 (hetero)aryl(cyclo)alkenyl groups, C4-C24 (cyclo)alkynyl(hetero)aryl groups, C4-C24 (hetero)aryl(cyclo)alkynyl groups, C4-C24 alkylcycloalkyl groups, and C4-C24 cycloalkylalkyl groups;
• wherein the R37 and R38 groups not being hydrogen are optionally substituted with a moiety selected from the group consisting of —Cl, —F, —Br, —I, —OH, —NH2, —SO3H, —PO3H, —PO4H2, —NO2, —CF3, ═O, ═NH, and —SH, and optionally contain one or more heteroatoms selected from the group consisting of O, S, NH, P, and Si, wherein the N, S, and P atoms are optionally oxidized, wherein the N atoms are optionally quaternized,
• wherein R38 is independently selected from the group listed for R37 and R36, with the proviso that R38 is not attached to the remainder of the molecule via C(O), C(S), S(O), or S(O)2;
• wherein each R47 is independently selected from the group consisting of hydrogen, —(SP)i—CB, —F, —Cl, —Br, —I, —OR37, —N(R37)2, —SO3, —PO3—, —NO2, —CF3, —SR37, —S(═O)2N(R37)2, —OC(═O)R37, —SC(═O)R37, —OC(═S)R37, —SC(═S)R37, —NR37C(═O)—R37, —NR37C(═S)—R37, —NR37C(═O)O—R37, —NR37C(═S)O—R37, —NR37C(═O)S—R37, —NR37C(═S)S—R37, —OC(═O)N(R37)2, —SC(═O)N(R37)2, —OC(═S)N(R37)2, —SC(═S)N(R37)2, —NR37C(═O)N(R37)2, —NR37C(═O)N(R37)2, —C(═O)R37, —C(═S)R37, —C(═O)N(R37)2, —C(═S)N(R37)2, —C(═O)O—R37, —C(═O)S—R37, —C(═S)O—R37, —C(═S)S—R37, —S(O)R37, —S(O)2R37, —NR37S(O)2R37, —ON(R37)2,
• —NR37OR37, C1-C24 alkyl groups, C2-C24 alkenyl groups, C2-C24 alkynyl groups, C6-C24 aryl groups, C2-C24 heteroaryl groups, C3-C24 cycloalkyl groups, C5-C24 cycloalkenyl groups, C12-C24 cycloalkynyl groups, C3-C24 (cyclo)alkyl(hetero)aryl groups, C3-C24 (hetero)aryl(cyclo)alkyl, C4-C24 (cyclo)alkenyl(hetero)aryl groups, C4-C24 (hetero)aryl(cyclo)alkenyl groups, C4-C24 (cyclo)alkynyl(hetero)aryl groups, C4-C24 (hetero)aryl(cyclo)alkynyl groups, C4-C24 alkylcycloalkyl groups, and C4-C24 cycloalkylalkyl groups;
• wherein the alkyl groups, alkenyl groups, alkynyl groups, aryl, heteroaryl, cycloalkyl groups, cycloalkenyl groups, cycloalkynyl groups, (cyclo)alkyl(hetero)aryl groups, (hetero)aryl(cyclo)alkyl groups, (cyclo)alkenyl(hetero)aryl groups, (hetero)aryl(cyclo)alkenyl groups, (cyclo)alkynyl(hetero)aryl groups, (hetero)aryl(cyclo)alkynyl groups, alkylcycloalkyl groups, cycloalkylalkyl groups are optionally substituted with a moiety selected from the group consisting of —Cl, —F, —Br, —I, —OR37, —N(R37)2, —SO3R37, —PO3(R37)2, —PO4(R37)2, —NO2, —CF3, ═O, ═NR37, and —SR37, and optionally contain one or more heteroatoms selected from the group consisting of O, S, NR37, P, and Si, wherein the N, S, and P atoms are optionally oxidized, wherein the N atoms are optionally quaternized,
• wherein two R37, R38, R47 groups are optionally comprised in a ring,
• wherein two R37, R38, R47 groups are optionally comprised in a ring so as to form a ring fused to the eight-membered trans-ring.