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US 12,653,907 B2Granted
Methods of treating or preventing age-related disorders
AssigneeBioviva USA Inc.
InventorElizabeth Louise Parrish
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Abstract
Disclosed are methods for reducing effects of aging in a subject by administering a therapeutically effective amount of a human Telomerase Reverse Transcriptase (hTERT) gene in combination with a Follistatin-344 gene. The subject may be a human. The methods can beneficially increase telomere length in the treated subject.
Claims14
A method comprising:
- administering to a human a therapeutically effective amount of a human Telomerase Reverse Transcriptase (hTERT) gene in combination with a Follistatin-344 gene,
- wherein the hTERT gene is administered via intramuscular injection and the Follistatin-344 gene is administered via subcutaneous injection and intravenous injection,
- wherein the method provides one or more of
- (i) increasing telomere length in at least some cells of the human,
- (ii) decreasing muscle loss, maintaining muscle mass, or increasing muscle mass in the human, or
- (iii) improving blood glucose levels in the human.
3 more elements
A method comprising:
- administering to a human a therapeutically effective amount of a human Telomerase Reverse Transcriptase (hTERT) gene in combination with a Follistatin-344 gene,
- wherein the hTERT gene is administered via intramuscular injection and the Follistatin-344 gene is administered via subcutaneous injection and intravenous injection,
- wherein the hTERT and Follistatin-344 genes are administered using an adeno-associated viral (AAV) vector, and wherein the method increases telomere length in at least some cells of the human.
A method comprising:
- administering to a human a therapeutically effective amount of
- (i) a human Telomerase Reverse Transcriptase (hTERT) gene via intramuscular injection, and
- (ii) a Follistatin-344 gene via subcutaneous injection, intravenous injection, or both,
- wherein the method provides one or more of
- (i) increasing telomere length in at least some cells of the human,
- (ii) decreasing muscle loss, maintaining muscle mass, or increasing muscle mass in the human, or
- (iii) improving blood glucose levels in the human.
4 more elements
Dependencies are inferred from the claim text.