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US 12,653,902 B2Granted
Photo-immunoconjugate formulations and methods of treatment relating thereto
AssigneeUniversity of Maryland, College Park
InventorsHuang-Chiao Huang, Barry Jiahao Liang
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Abstract
The present disclosure relates to photo-immunoconjugate formulations comprising a nanoparticle carrier comprising first and second therapeutic agents coupled to the nanoparticle carrier, and a photosensitizer molecule coupled to the first therapeutic agent or the nanoparticle carrier, and methods of treating cancer via administration of the photo-immunoconjugate formulations.
Claims14
A photo-immunoconjugate formulation, comprising:
- a nanoparticle carrier;
- a first therapeutic agent coupled to said nanoparticle carrier;
- a photosensitizer molecule coupled to a first therapeutic agent, wherein said photosensitizer is coupled to a surface of said nanoparticle carrier;
- and
- a second therapeutic agent;
- wherein said nanoparticle carrier is a polymeric nanoparticle;
- wherein said first therapeutic agent is an anti-EGFR monoclonal antibody, or an antigen-binding fragment thereof;
- wherein said second therapeutic agent is a topoisomerase inhibitor;
- wherein the first and/or second therapeutic agent is encapsulated within said polymeric nanoparticle;
- and
- wherein said anti-EGFR monoclonal antibody is cetuximab or panitumumab.
8 more elements
Dependencies are inferred from the claim text.